In an article, author is Miao, Xuepei, once mentioned the application of 2799-16-8, Computed Properties of C3H9NO, Name is (R)-1-Aminopropan-2-ol, molecular formula is C3H9NO, molecular weight is 75.1097, MDL number is MFCD00064428, category is amides-buliding-blocks. Now introduce a scientific discovery about this category.
Does a Conjugation Site Affect Transport of Vitamin B-12-Peptide Nucleic Acid Conjugates into Bacterial Cells?
Gram-negative bacteria develop specific systems for the uptake of scarce nutrients, including vitamin B-12. These uptake pathways may be utilized for the delivery of biologically relevant molecules into cells. Indeed, it was recently reported that vitamin B-12 transported an antisense peptide nucleic acid (PNA) into Escherichia coli and Salmonella Typhimurium cells. The present studies indicate that the conjugation site of PNA to vitamin B-12 has an impact on PNA transport into bacterial cells. Toward this end, a specifically designed PNA oligomer has been tethered at various positions of vitamin B-12 (central Co, R-5 ‘-OH, c and e amide chains, meso position, and at the hydroxy group of cobinamide) by using known or newly developed methodologies and tested for the uptake of the synthesized conjugates by E. coli. Compounds in which the PNA oligonucleotide was anchored at the R-5 ‘-OH position were transported more efficiently than that of other compounds tethered at the peripheral positions around the corrin ring. Of importance is the fact that, contrary to mammalian organisms, E. coli also takes up cobinamide, which is an incomplete corrinoid. This selectivity opens up ways to fight bacterial infections.
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