Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Chemin, Jean, once mentioned the application of 51857-17-1, Name is N-Boc-1,6-Diaminohexane, molecular formula is C11H24N2O2, molecular weight is 216.3205, MDL number is MFCD00671489, category is amides-buliding-blocks. Now introduce a scientific discovery about this category, Quality Control of N-Boc-1,6-Diaminohexane.
Chemical Protectors against the Toxic Effects of Paracetamol (Acetaminophen) and Its Meta Analogue: Preventing Protein Arylation
The potential role of nine thiols as chemical protectors against the toxicity of paracetamol (acetaminophen, APAP) and its meta analogue N-acetyl-m-aminophenol (AMAP) was investigated using the density functional theory. They are glutathione (GSH), N-acetylcysteine (NAC), NAC amide (NACA), tiopronine (TPR), dihydrolipoic acid (DHL), 6-mercaptopurine (6MP), 6-thioguanine (6TG), 2,3-dimercaprol (DMC), and D-penicillamine (PNA). The investigation was focused on the toxic effects derived from protein arylation at cysteine residues, induced by the quinone imines formed from APAP and AMAP. On the basis of both thermochemical and kinetic considerations, with the exceptions of 6MP and 6TG, the investigated thiols may be useful in protecting the chemical integrity of cysteine residues in proteins from arylation by quinone imines. The order of efficiency for that purpose is predicted to be NAC > GSH > TPR > NACA > DMC > DHL. However, considering physicochemical properties that may affect bioavailability and cell permeability, DHL seems to be the best prospect to be orally supplied.
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