Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Formula: C4H14Cl2N2, 333-93-7, Name is 1,4-Diaminobutane dihydrochloride, molecular formula is C4H14Cl2N2, belongs to amides-buliding-blocks compound. In a document, author is Liu, Haijuan, introduce the new discover.
Aza-heterocyclic frameworks through intramolecular pi-system trapping of spiro-N-acyliminiums generated from isoindolinone
Spiro-acetoxylactams as key substrates were obtained straightforwardly by the tandem regioselective reduction/O-acylation of spiro-isoindolinone-imides. The latter were produced in large scale in three steps from homophthalic acid. These imides were useful to provide in one step isoindolinones bearing hydroxymethyl-amide functions, tethered at quaternary carbon centre with promising biological issues. Submitted to Bronsted (TFA neat) and Lewis acid (trimethylsilyltrifluoro-methanesulfonic (TMSOTf) 10 mol%), the spiro-acetoxylactams undergo pi-cyclization of spiro-N-acyliminiums to provide diastereoselectively with pi-aromatic original pyrrolopyrido- and pyrroloazepino-isoindoles fused or not to aromatic systems. With pi-olefins, pyrrolopyridines and pyrrolo-azepines fused to isoindoline or containing amino-acids were isolated. A reaction mechanism producing all these systems is also discussed.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 333-93-7. Formula: C4H14Cl2N2.