Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 17194-82-0, Name is 4-Hydroxyphenylacetamide, molecular formula is C8H9NO2, belongs to amides-buliding-blocks compound, is a common compound. In a patnet, author is Ruiz-Perez, Karen M., once mentioned the new application about 17194-82-0, Formula: C8H9NO2.
Lanthanide-Based T-2ex and CEST Complexes Provide Insights into the Design of pH Sensitive MRI Agents
The CEST and T-1/T-2 relaxation properties of a series of Eu3+ and Dy3+ DOTA-tetraamide complexes with four appended primary amine groups are measured as a function of pH. The CEST signals in the Eu3+ complexes show a strong CEST signal after the pH was reduced from 8 to 5. The opposite trend was observed for the Dy3+ complexes where the r(2ex) of bulk water protons increased dramatically from ca. 1.5 mM(-1) s(-1) to 13 mM(-1) s(-1) between pH 5 and 9 while r(1) remained unchanged. A fit of the CEST data (Eu3+ complexes) to Bloch theory and the T-2ex data (Dy3+ complexes) to Swift-Connick theory provided the proton-exchange rates as a function of pH. These data showed that the four amine groups contribute significantly to proton-catalyzed exchange of the Ln(3+)-bound water protons even though their pK(a)’s are much higher than the observed CEST or T-2ex effects. This demonstrated the utility of using appended acidic/basic groups to catalyze prototropic exchange for imaging tissue pH by MRI.
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 17194-82-0. The above is the message from the blog manager. Formula: C8H9NO2.