Chemistry is an experimental science, Category: amides-buliding-blocks, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 33208-99-0, Name is H-Ala-NH2.HCl, molecular formula is C3H9ClN2O, belongs to amides-buliding-blocks compound. In a document, author is Wang, Manman.
Catalytic Enantioselective Synthesis of 3,4-Polyfused Oxindoles with Quaternary All-Carbon Stereocenters: A Rh-Catalyzed C-C Activation Approach
The first Rh-catalyzed enantioselective synthesis of a 3,4-polyfused oxindole ring system enabled by carboacylation of acrylic amides based on C-C activation is reported. This transformation provides a new entry to access 3,4-polyfused oxindoles bearing quaternary stereocenters. Tri- to pentacyclic 3,4-fused oxindoles were asymmetrically generated in good yields (up to 95%) with good to excellent enantioselectivity (88%-97% ee). Application in the first total synthesis of xylanigripones A was completed in 6 steps with a 14% overall yield.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 33208-99-0. Category: amides-buliding-blocks.