Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 51-35-4, Name is H-Hyp-OH, molecular formula is C5H9NO3. In an article, author is Zhang, Yueteng,once mentioned of 51-35-4, Recommanded Product: H-Hyp-OH.
Selective N-Alkylation of 2-Amino-4H-chromene-3-carbonitrile Derivatives with Alcohols Catalyzed by AlCl3 Under the Assistance of CH3COOH
A highly efficient and selective N-alkylation reaction of 2-amino-4H-chromene-3-carbonitrile derivatives using various alcohols as alkylation agent were developed in the presence of AlCl3 as a catalyst as well as CH3COOH as an additive, in which the cyano group kept inert and the amino group was alkylated in high yields. All the target products were characterized and determined by infrared(IR), H-1 NMR, C-13 NMR, and HRMS. And the X-ray structure of product 3ab was obtained. A bimolecular reaction mechanism catalyzed by AlCl3 was proposed under the assistance of CH3COOH.
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