Reference of 57-00-1, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 57-00-1, Name is 2-(1-Methylguanidino)acetic acid, SMILES is O=C(O)CN(C)C(N)=N, belongs to amides-buliding-blocks compound. In a article, author is Padmanabhan, Venkat, introduce new discover of the category.
Facile access to some new 3,3 ‘-bipyrazole-ester derivatives utilizing bis-hydrazonoyl chlorides
The 1,3-dipolar cycloaddition reaction of bis-hydrazonoyl chlorides with ethyl propiolate and dimethyl acetylenedicarboxylate afforded diethyl 1,1 ‘-aryl-3,3 ‘-bipyrazole-4,4 ‘-dicarboxylate and tetramethyl 1,1 ‘-diaryl-3,3 ‘-bipyrazole-4,4 ‘,5,5 ‘-tetracarboxylate esters, respectively. Heating the latter two compounds with a mixture of HCl/AcOH furnished the same product: 3,3 ‘-bipyrazole-5,5 ‘-dicarboxylic acid. Reaction of the tetracarboxylate ester with aniline derivatives and with hydrazine gave the corresponding bipyrazole-fused heterocycles. Heating the dicarboxylic acid with 2-aminothiazole gave the corresponding bis-amide derivative. The structures of the products were established by elemental analysis, spectral data, and single-crystal X-ray crystallography.
Reference of 57-00-1, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 57-00-1 is helpful to your research.