In an article, author is Balalaie, Saeed, once mentioned the application of 56-45-1, Name is H-Ser-OH, molecular formula is C3H7NO3, molecular weight is 105.0926, MDL number is MFCD00064224, category is amides-buliding-blocks. Now introduce a scientific discovery about this category, Application In Synthesis of H-Ser-OH.
Rhodium-Catalyzed Enantioselective Defluorinative alpha-Arylation of Secondary Amides
We exploited the reactivity of an electronically biased Michael acceptor to perform a defluorinative alpha-arylation reaction using a chiral diene(L*)-rhodium catalyst. Through this methodology, we are able to obtain various secondary amides, containing a tertiary alpha-stereocenter and a ,alpha-unsaturated gem-difluoro olefin, with excellent enantioselectivities. This methodology addresses the limitations of the previously described alpha-arylation methods to construct stereo-labile tertiary alpha-stereocenters. Further investigation of the reaction via in situ F-19 NMR monitoring suggests that the formation of the product leads to the inhibition of the active rhodium catalyst.
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