Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 148-18-5, Name is Sodium diethylcarbamodithioate, SMILES is [S-]C(N(CC)CC)=S.[Na+], belongs to amides-buliding-blocks compound. In a document, author is Jas, Gouri S., introduce the new discover, Safety of Sodium diethylcarbamodithioate.
Palladium-catalyzed Suzuki-Miyaura coupling of thioureas or thioamides
Cross-coupling reactions involving metal carbene intermediates play an increasingly important role in C-C bond formation. Expanding the carbene precursors to a broader range of starting materials and more diverse products is an ongoing challenge in synthetic organic chemistry. Herein, we report a Suzuki-Miyaura coupling reaction of in situ-generated Pd-carbene complexes via desulfurization of thioureas or thioamides. This strategy enables the preparation of a broad array of substituted amidinium salts and unsymmetrical diaryl ketones. The reaction is readily scalable, compatible with bromo groups on aromatic rings, tolerant to moisture and air and has a broad substrate scope. Furthermore, a single crystal structure of Pd-diaminocarbene complex is obtained and proven to be the key intermediate in both catalytic and stoichiometric reactions. Preliminary mechanistic studies demonstrate the dual role of the silver salt as a desulfurating reagent assisting the elimination of sulfur and as oxidant facilitating the Pd-II/Pd-0/Pd(II )catalytic cycle.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 148-18-5 is helpful to your research. Safety of Sodium diethylcarbamodithioate.