Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 104-10-9, Name is 2-(4-Aminophenyl)ethanol, SMILES is NC1=CC=C(CCO)C=C1, belongs to amides-buliding-blocks compound. In a document, author is Gagnot, Glwadys, introduce the new discover, Computed Properties of C8H11NO.
The effect of terminal groups and halogenation of KLVFF peptide on its activity as an inhibitor of beta-amyloid aggregation
The aggregation of A beta peptide into amyloid fibrils in the brain is associated with Alzheimer’s disease (AD). Inhibition of A beta aggregation seemed a potential treatment for AD. It was previously shown that a short fragment of A beta peptide (KLVFF, 16-20) bound A beta inhibited its aggregation. In this work, using KLVFF peptide, we synthesized two peptide families and then evaluated their inhibitory capacities by conventional assays such as thioflavin T (ThT) fluorescence spectroscopy, turbidity measurement, and the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS). The effect of peptide terminal groups on its inhibitory activity was first studied. Subsequently, the influence of halogenated amino acids on peptide anti-aggregation properties was investigated. We found that iodinated peptide with amine in the N and amide in the C termini, respectively, was the best inhibitor of A beta fibers formation. Halogenated peptides seemed to decrease the number of A beta fibrils; however, they did not reduce A beta cytotoxicity. The data obtained in this work seemed promising in developing potential peptide drugs for treatment of AD.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 104-10-9 is helpful to your research. Computed Properties of C8H11NO.