Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Recommanded Product: 33208-99-033208-99-0, Name is H-Ala-NH2.HCl, SMILES is C[C@H](N)C(N)=O.[H]Cl, belongs to amides-buliding-blocks compound. In a article, author is Wei Yanshan, introduce new discover of the category.
Palladium-Catalyzed Site-Selective [3+2] Annulation via Benzylic and meta C-H Bond Activation
The palladium-catalyzed [3+2] annulation of aromatic amides with maleimides via the activation of ortho benzylic C-H and meta C-H bonds is reported. Carboxamide and anilide type substrates that contain a 2-methylthiophenyl group both participate in this [3+2] annulation, indicating that the presence of a 2-methylthiophenyl directing group is a key for the success of the reaction. The first C-H bond activation at the benzylic C-H bond is followed by a second C-H bond activation at the meta C-H bond to give five-membered cyclic products. The cleavage of these C-H bonds is irreversible.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 33208-99-0. Recommanded Product: 33208-99-0.