One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 70-47-3, Name is H-Asn-OH, formurla is C4H8N2O3. In a document, author is Padmanabhan, Venkat, introducing its new discovery. Safety of H-Asn-OH.
Facile access to some new 3,3 ‘-bipyrazole-ester derivatives utilizing bis-hydrazonoyl chlorides
The 1,3-dipolar cycloaddition reaction of bis-hydrazonoyl chlorides with ethyl propiolate and dimethyl acetylenedicarboxylate afforded diethyl 1,1 ‘-aryl-3,3 ‘-bipyrazole-4,4 ‘-dicarboxylate and tetramethyl 1,1 ‘-diaryl-3,3 ‘-bipyrazole-4,4 ‘,5,5 ‘-tetracarboxylate esters, respectively. Heating the latter two compounds with a mixture of HCl/AcOH furnished the same product: 3,3 ‘-bipyrazole-5,5 ‘-dicarboxylic acid. Reaction of the tetracarboxylate ester with aniline derivatives and with hydrazine gave the corresponding bipyrazole-fused heterocycles. Heating the dicarboxylic acid with 2-aminothiazole gave the corresponding bis-amide derivative. The structures of the products were established by elemental analysis, spectral data, and single-crystal X-ray crystallography.
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