5680-79-5, Name is H-Gly-OMe.HCl, molecular formula is C3H8ClNO2, COA of Formula: C3H8ClNO2, belongs to amides-buliding-blocks compound, is a common compound. In a patnet, author is Barsu, Nagaraju, once mentioned the new application about 5680-79-5.
Stereoselective Sulfinyl Aniline-Promoted Pd-Catalyzed C-H Arylation and Acetoxylation of Aliphatic Amides
Stereoselective functionalization of aliphatic C-H bonds presents a great challenge. Following this target, we disclose herein an original strategy towards direct arylation of aliphatic chains at ss-methylene position based on a use of amide-sulfoxide bicoordinating directing group. Although moderate to high chiral induction (up to 9:1d.r.) is achieved, diastereomerically pure compounds may be afforded by simple separation of diastereomeric products by silica gel chromatography. Accordingly, this reaction allows preparation of a large scope of high-value scaffolds in synthetically useful yields while recyclable character of our chiral auxiliary brings an additional benefit. A potential of this methodology to build up original molecules by sequential diarylation and expedient (two step) synthesis of a biologically active compound are further disclosed. Finally a first example of stereoselective direct acetoxylation of aliphatic chains is reported.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 5680-79-5 help many people in the next few years. COA of Formula: C3H8ClNO2.