Application of 6306-52-1, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 6306-52-1, Name is H-Val-OMe.HCl, SMILES is N[C@@H](C(C)C)C(OC)=O.[H]Cl, belongs to amides-buliding-blocks compound. In a article, author is Tsai, Jui-Chi, introduce new discover of the category.
Aminopeptidase-N-activated Theranostic Prodrug for NIR Tracking of Local Tumor Chemotherapy
The development of molecular theranostic prodrugs for in vivo cancer diagnosis and targeted chemotherapy is urgently required. Enzyme-activated prodrugs display superior selectivity as a result of cancer-specific enzymes which serve as cancer biomarkers. Herein, an aminopeptidase N (APN)-activated theranostic prodrug Nile blue-C-6-amide-p-fluorophenylalanyl-l-melphalanyl (NBFMel) is reported for fluorescence cancer diagnosis and local tumor treatment. NBFMel demonstrates negligible cytotoxicity and very weak fluorescence due to the photoinduced electron transfer (PET) between melphalan and Nile blue fluorophore. After activation caused by APN, the prodrug releases free melphalan that inhibits tumor cell growth. Simultaneously, the reaction blocks the PET process and switches on the fluorescence, which can be used for cancer diagnosis. NBFMel is successfully utilized to report the presence of tumor and for in situ tracking of drug release in tumor-bearing mouse models. Moreover, NBFMel demonstrates efficient tumor inhibition when intravenously injected into mice. Therefore, the APN-activated theranostic prodrug provides a new platform for in vivo cancer diagnosis and targeted anticancer chemotherapy.
Application of 6306-52-1, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 6306-52-1.