Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, COA of Formula: C6H7NO2S, 98-10-2, Name is Benzenesulfonamide, SMILES is O=S(C1=CC=CC=C1)(N)=O, belongs to amides-buliding-blocks compound. In a document, author is Hu, Rong, introduce the new discover.
(4+2) cyclization of aza-o-quinone methides with azlactones: construction of biologically important dihydroquinolinone frameworks
A base-promoted (4 + 2) cyclization of aza-o-quinone methides (aza-o-QMs) in situ generated from N-(o-chloromethyl)aryl amides was established. In this approach, azlactones were utilized as competent two-atom reaction partners to undergo (4 + 2) cyclization with aza-o-QMs, which afforded a series of dihydroquinolinone derivatives in overall good yields (up to 98%). This protocol has not only advanced the development of aza-o-QM-involved reactions, but also offered a useful method for constructing biologically important dihydroquinolinone frameworks.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 98-10-2. COA of Formula: C6H7NO2S.