Chemistry, like all the natural sciences, Quality Control of H-Tle-OH, begins with the direct observation of nature¡ª in this case, of matter.20859-02-3, Name is H-Tle-OH, SMILES is CC(C)(C)[C@H](N)C(O)=O, belongs to amides-buliding-blocks compound. In a document, author is Bakic, Marina Tranfic, introduce the new discover.
Measurement of N-14 quadrupole couplings in biomolecular solids using indirect-detection 14N solid-state NMR with DNP
The quadrupolar interaction experienced by the spin-1 N-14 nucleus is known to be extremely sensitive to local structure and dynamics. Furthermore, the N-14 isotope is 99.6% naturally abundant, making it an attractive target for characterisation of nitrogen-rich biological molecules by solid-state NMR. In this study, dynamic nuclear polarization (DNP) is used in conjunction with indirect N-14 detected solid-state NMR experiments to simultaneously characterise the quadrupolar interaction at multiple N-14 sites in the backbone of the microcrystalline protein, GB3. Considerable variation in the quadrupolar interaction (>700 kHz) is observed throughout the protein backbone. The distribution in quadrupolar interactions observed reports on the variation in local backbone conformation and subtle differences in hydrogen-bonding; demonstrating a new route to the structural and dynamic analysis of biomolecules.
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