Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 333-93-7, Name is 1,4-Diaminobutane dihydrochloride. In a document, author is Meng, Ya, introducing its new discovery. Formula: C4H14Cl2N2.
Structural insights of sulfonamide-based NLRP3 inflammasome inhibitors: design, synthesis, and biological characterization
NLRP3 inflammasome has recently attracted much attention as a potentially druggable target to develop potential therapeutics for inflammatory and neurodegenerative disorders. In our continuing studies, structure-activity relationship studies were conducted based on a newly identified NLRP3 inhibitor, YQ-II-128, from our laboratory to understand the structural features and improve aqueous solubility. The results revealed that steric interactions at the propoxyl and amide domain of YQ-II-128 are important for the observed inhibitory potency on the NLRP3 inflammasome. The results also identified the amide domain to incorporate polar moieties to improve solubility and potentially pharmacokinetic properties. As a result, analog 10 was identified as a selective NLRP3 inhibitor with comparable potency while significantly improved aqueous solubility. Collectively, these findings strongly encourage further optmization of 10 to develop analogs with improved pharmacokinetic properties as potential NLRP3-targted therapeutics.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 333-93-7 help many people in the next few years. Formula: C4H14Cl2N2.