Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Name: H-Hyp-OH, 51-35-4, Name is H-Hyp-OH, molecular formula is C5H9NO3, belongs to amides-buliding-blocks compound. In a document, author is Vallejo Narvaez, Wilmer E., introduce the new discover.
Montmorillonite-KSF mediated one step synthesis of pyranochromene derivatives
One-pot three-component reaction of substituted aromatic aldehydes, 2-cyanoacetamide and 4-hydroxycoumarin in the presence of Montmorillonite-KSF (MKSF) in ethanol results in the formation of pyrano[3,2-c]chromene-3-carboxylates (5a-m) has been described. The reaction was tested in different alcohols, afforded pyrano [3,2-c] chromene-3-carboxylates (5a-m) of the corresponding alcohols in good yield. The mechanism reveals that the alcohol (as solvent) plays a major role in the inter conversion of amide to the corresponding esters with Montmorillonite KSF (M-KSF) as a catalyst. Excellent yields, inexpensive and readily available substrates, environmentally benign reaction condition, shorter reaction time, and easy workup are the major advantageous features of this protocol. (C) 2018 Elsevier B.V. All rights reserved.
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