The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Computed Properties of C7H9NO, 536-90-3, Name is 3-Methoxyaniline, SMILES is NC1=CC=CC(OC)=C1, in an article , author is Greciano, Elisa E., once mentioned of 536-90-3.
Unprotected Indazoles Are Resilient to Ring-Opening Isomerization: A Case Study on Catalytic C-S Couplings in the Presence of Strong Base
Indazoles represent a privileged scaffold in medicinal chemistry. In the presence of strong base, however, N-protected indazoles are prone to an undesirable ring-opening reaction to liberate o-aminobenzonitriles. By employing unprotected indazoles with a free N-H bond, isomerization is averted because the heterocycle is deprotonated in situ. We herein report functional group-tolerant and robust C-S couplings of bromoindazoles with thiols of varying electronic nature in the presence of lithium bis(trimethylsilyl)amide at elevated temperatures.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 536-90-3, you can contact me at any time and look forward to more communication. Computed Properties of C7H9NO.