Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 16066-84-5, Name is tert-Butyl methylcarbamate, molecular formula is , belongs to amides-buliding-blocks compound. In a document, author is Shibata, Kaname, COA of Formula: C6H13NO2.
Spiropiperidine Sultam and Lactam Templates: Diastereoselective Overman Rearrangement and Metathesis followed by NH Arylation
We report the diastereoselective synthesis of novel spiropiperidine templates for use in SAR studies of beta-secretase (BACE) inhibitors and also as versatile ligands for other receptor types. The overall synthetic approach stems from chiral starting material benzyl (S)-2-methyl-4-oxopiperidine-1-carboxylate and employs an Overman rearrangement to control the stereochemistry at the quaternary center. This process is followed by a Grubbs metathesis to close a five-membered top ring to form an alpha,beta-unsaturated lactam or an alpha,beta-unsaturated sultam. We also demonstrate that this chemistry can accommodate additional substituents on the lactam/sultam ring and allows late stage sequential functionalization of the amine and amide nitrogens to rapidly produce diverse analogues.
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