Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 6582-52-1, Name is 2,2′-Methylenedianiline, molecular formula is , belongs to amides-buliding-blocks compound. In a document, author is Kadnor, Vijay A., Computed Properties of C13H14N2.
Oxidation of 5-methylaminomethyl uridine (mnm(5)U) by Oxone Leads to Aldonitrone Derivatives
Oxidative RNA damage is linked to cell dysfunction and diseases. The present work focuses on the in vitro oxidation of 5-methylaminomethyl uridine (mnm(5)U), which belongs to the numerous post-transcriptional modifications that are found in tRNA. The reaction of oxone with mnm(5)U in water at pH 7.5 leads to two aldonitrone derivatives. They form by two oxidation steps and one dehydration step. Therefore, the potential oxidation products of mnm(5)U in vivo may not be only aldonitrones, but also hydroxylamine and imine derivatives (which may be chemically more reactive). Irradiation of aldonitrone leads to unstable oxaziridine derivatives that are susceptible to isomerization to amide or to hydrolysis to aldehyde derivative.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 6582-52-1, in my other articles. Computed Properties of C13H14N2.