Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 150-25-4, Name is 2-(Bis(2-hydroxyethyl)amino)acetic acid, molecular formula is , belongs to amides-buliding-blocks compound. In a document, author is Gao, Biao, Application In Synthesis of 2-(Bis(2-hydroxyethyl)amino)acetic acid.
C2-Modified Sparteine Derivatives Are a New Class of Potentially Long-Acting Sodium Channel Blockers
The lupin alkaloid sparteine is a well-known chiral diamine with a range of applications in asymmetric synthesis, as well as a blocker of voltage-gated sodium channels (VGSCs). However, there is only scarce information on the VGSC-blocking activity of sparteine derivatives where the structure of the parent alkaloid is retained. Building on the recent renewed availability of sparteine and derivatives we report herein how modification of sparteine at position2 produces irreversible blockers of VGSCs. These compounds could be clinically envisaged as long-lasting local anesthetics.
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