A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 24277-39-2, Name is Boc-Glu-OtBu, molecular formula is C14H25NO6. In an article, author is Kondakala, Sandeep,once mentioned of 24277-39-2, HPLC of Formula: C14H25NO6.
The asymmetric synthesis of (S,S)-methylphenidate hydrochloride via ring-opening of an enantiopure aziridinium intermediate with phenylmagnesium bromide
The key step in our synthetic strategy towards (S,S)-methylphenidate hydrochloride employs the ring-opening of an in situ formed aziridinium intermediate. Treatment of an alpha-hydroxy-beta-amino ester with methanesulfonic anhydride promoted aziridinium formation and the subsequent addition of phenyl-magnesium bromide resulted in stereospecific and regioselective ring-opening to give the corresponding alpha-phenyl-beta-amino ester with overall retention of configuration. Subsequent functional group manipulation followed by N-deprotection and cyclisation generated the piperidine ring within the target compound, and transesterification gave (S,S)-methylphenidate hydrochloride, in only 8 steps from 1,5-pentanediol, in 15% overall yield. These results demonstrate the synthetic utility of enantiopure aziridinium intermediates as substrates for the generation of stereodefined C-C bonds, and crucially this methodology provides access to alpha-substituted-beta-amino ester substrates that are not accessible via enolate alkylation chemistry. The strategy reported herein is potentially applicable to all possible stereoisomers of methylphenidate as well as differentially substituted analogues. (C) 2019 Elsevier Ltd. All rights reserved.
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