Electric Literature of 98-10-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 98-10-2, Name is Benzenesulfonamide, SMILES is O=S(C1=CC=CC=C1)(N)=O, belongs to amides-buliding-blocks compound. In a article, author is Liu, Tie, introduce new discover of the category.
The Most Twisted Acyclic Amides: Structures and Reactivity
The synthesis, crystal structures, and reactivity of the most twisted acyclic amides described to date are reported. Substitution at the nitrogen atom in simple benzamides with Ts and acyl or carbamate groups provides a unique way to achieve almost perpendicular twist in N-acyclic amides (tau = 77 degrees, N = Ac; tau = 87 degrees, N = Boc). The overlap between the Nlp and CO pi* orbital is disrupted due to geometrical constraints around the N-substituents. The perpendicular acyclic twisted amides represent a transition state mimic of cis-trans peptide isomerization thus far only accessible by excessively twisted bridged lactams.
Electric Literature of 98-10-2, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 98-10-2.