Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.123-39-7, Name is N-Methylformamide, SMILES is O=CNC, belongs to amides-buliding-blocks compound. In a document, author is Price, Neil P. J., introduce the new discover, COA of Formula: C2H5NO.
Pd-Catalyzed tandem reaction of N-(2-cyanoaryl)benzamides with arylboronic acids: synthesis of quinazolines
The synthesis of 2,4-disubstituted quinazolines by a palladium-catalyzed reaction of arylboronic acids with N-(2-cyanoaryl)benzamides has been developed with moderate to excellent yields. The method shows good functional group tolerance. In particular, halogen and hydroxyl substituents, which are amenable for further synthetic elaborations, are well tolerated. Moreover, the present synthetic route could be readily scaled up to gram quantity without difficulty. The mechanism possibly involves nucleophilic addition to the nitrile function, forming an imine intermediate followed by an intramolecular addition to the amide and dehydration to the quinazoline ring.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 123-39-7 is helpful to your research. COA of Formula: C2H5NO.