Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , SDS of cas: 1492-24-6, 1492-24-6, Name is H-Abu-OH, molecular formula is C4H9NO2, belongs to amides-buliding-blocks compound. In a document, author is Sen, Malay, introduce the new discover.
Nickel-catalyzed C-O/N-H, C-S/N-H, and C-CN/N-H annulation of aromatic amides with alkynes: C-O, C-S, and C-CN activation
The Ni-catalyzed reaction of ortho-phenoxy-substituted aromatic amides with alkynes in the presence of (LiOBu)-Bu-t as a base results in C-O/N-H annulation with the formation of 1(2H)-isoquinolinones. The use of a base is essential for the reaction to proceed. The reaction proceeds, even in the absence of a ligand, and under mild reaction conditions (40 degrees C). An electron-donating group on the aromatic ring facilitates the reaction. The reaction was also applicable to carbamate (C-O bond activation), methylthio (C-S bond activation), and cyano (C-CN bond activation) groups as leaving groups.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1492-24-6. SDS of cas: 1492-24-6.