Chemistry, like all the natural sciences, Formula: CH5NO2S, begins with the direct observation of nature¡ª in this case, of matter.3144-09-0, Name is Methylsulfonamide, SMILES is CS(=O)(N)=O, belongs to amides-buliding-blocks compound. In a document, author is Kumpulainen, Tatu, introduce the new discover.
Enzymatic Late-Stage Modifications: Better Late Than Never
Enzyme catalysis is gaining increasing importance in synthetic chemistry. Nowadays, the growing number of biocatalysts accessible by means of bioinformatics and enzyme engineering opens up an immense variety of selective reactions. Biocatalysis especially provides excellent opportunities for late-stage modification often superior to conventional de novo synthesis. Enzymes have proven to be useful for direct introduction of functional groups into complex scaffolds, as well as for rapid diversification of compound libraries. Particularly important and highly topical are enzyme-catalysed oxyfunctionalisations, halogenations, methylations, reductions, and amide bond formations due to the high prevalence of these motifs in pharmaceuticals. This Review gives an overview of the strengths and limitations of enzymatic late-stage modifications using native and engineered enzymes in synthesis while focusing on important examples in drug development.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 3144-09-0. Formula: CH5NO2S.