One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 6893-26-1, Name is (R)-2-Aminopentanedioic acid, formurla is C5H9NO4. In a document, author is Ravera, Mauro, introducing its new discovery. Name: (R)-2-Aminopentanedioic acid.
Chemical exchange rotation transfer (CERT) on human brain at 3 Tesla
Purpose: To test the ability of a novel pulse sequence applied in vivo at 3 Tesla to separate the contributions to the water signal from amide proton transfer (APT) and relayed nuclear Overhauser enhancement (rNOE) from background direct water saturation and semisolid magnetization transfer (MT). The lack of such signal source isolation has confounded conventional chemical exchange saturation transfer (CEST) imaging. Methods: We quantified APT and rNOE signals using a chemical exchange rotation transfer (CERT) metric, MTRdouble. A range of duty cycles and average irradiation powers were applied, and results were compared with conventional CEST analyses using asymmetry (MTRasym) and extrapolated magnetization transfer (EMR). Results: Our results indicate that MTRdouble is more specific than MTRasym and, because it requires as few as 3 data points, is more rapid than methods requiring a complete Z-spectrum, such as EMR. In white matter, APT (1.5 +/- 0.5%) and rNOE (2.1 +/- 0.7%) were quantified by using MTRdouble with a 30% duty cycle and a 0.5-mu T average power. In addition, our results suggest that MTRdouble is insensitive to B-0 inhomogeneity, further magnifying its speed advantage over CEST metrics that require a separate B-0 measurement. However, MTRdouble still has nontrivial sensitivity to B-1 inhomogeneities. Conclusion: We demonstrated that MTRdouble is an alternative metric to evaluate APT and rNOE, which is fast, robust to B-0 inhomogeneity, and easy to process.
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