Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Robles, Andrew J., once mentioned the application of 333-93-7, Name is 1,4-Diaminobutane dihydrochloride, molecular formula is C4H14Cl2N2, molecular weight is 161.0734, MDL number is MFCD00012526, category is amides-buliding-blocks. Now introduce a scientific discovery about this category, Computed Properties of C4H14Cl2N2.
Reagent-controlled regiodivergent intermolecular cyclization of 2-aminobenzothiazoles with beta-ketoesters and beta-ketoamides
Two regiodivergent approaches to intermolecular cyclization of 2-aminobenzothiazoles with beta-ketoesters and amides have been developed, controlled by the reagents employed. With the Bronsted base KOt-Bu and CBrCl3 as radical initiator, benzo[d] imidazo[2,1-b] thiazoles are synthesized via attack at the a-carbon and keto carbon of the beta-ketoester moiety. In contrast, switching to the Lewis acid catalyst, In(OTf)(3), results in the regioselective nucleophilic attack at both carbonyl groups forming benzo[4,5] thiazolo[3,2-a]pyrimidin-4-ones
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