Related Products of 2895-21-8,Some common heterocyclic compound, 2895-21-8, name is N-Isopropyl-2-chloroacetamide, molecular formula is C5H10ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: The reaction mixture of N-substituted-2-chloroacetamide 2 (5.0 mmol, 1.0 equiv), crude product of 2-bromo-4-(substituted methyl)phenol 7 (5.0mmol, 1.0 equiv) and K2CO3 (7.5 mmol, 1.0 equiv) in MeCN (40 mL) was refluxed and monitored by TLC. When the reaction was accomplished, the solvents were removed under vacuum. To the obtained residue, water (50 mL)was added. The mixture was then extracted by ethyl acetate (3 x 50 mL), and the combined organic layers were dried over MgSO4. Removal the MgSO4 and evaporation of the solvent at reduced pressure gave the crude product. The pure product 8 was obtained by column chromatography on silica gel (elute: ethyl acetate: petroleum = 1: 4).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route N-Isopropyl-2-chloroacetamide, its application will become more common.
Reference:
Article; Xia, Shuai; Liu, Ji-Qiang; Wang, Xiu-Hua; Tian, Ye; Wang, Yu; Wang, Jing-Huan; Fang, Liang; Zuo, Hua; Bioorganic and Medicinal Chemistry Letters; vol. 24; 6; (2014); p. 1479 – 1483;,
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