Related Products of 112257-19-9, These common heterocyclic compound, 112257-19-9, name is tert-Butyl methyl(2-(methylamino)ethyl)carbamate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation Example 1-3: Preparation of Compound (II-4)[0060][0061] Under an argon stream, 4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-ureidopentanamido)benzyl (4-nitrophenyl) carbonate (6.8 g, 9.22 mmol) was dissolved in 150 mL of anhydrousdimethylformamide, and stirred, together with t-butyl methyl(2-(methylamino)ethyl)carbamate (1.82 g, 9.68 mmol) at 20- 25¡ãC for 19 hrs. After completion of the reaction, the reaction mixture was completely concentrated in a high vacuum,and the concentrate was purified by silica gel column chromatography to obtain an amino-protected derivative of compound (II-4) (5.14 g, 71percent).[0062]1H NMR (400 MHz, DMSO-d6) delta0.78-0.8 (d, 3 H), 0.8-0.83 (d, 3 H), 1.09 -1.99 (m, 10 H), 1.33 (s, 9 H), 1.92(m, 1 H), 2.07-2.19 (m, 2H), 2.66-2.73 (d, 3H), 2.8-2.81 (m, 3H), 2.9-3.0 (m, 2H), 3.37 (m, 2 H), 4.15 (t, 1 H), 4.34 (m,1 H), 4.94 (s, 2 H), 5.38 (s, 2 H), 5.94 (brt, 1 H), 6.96 (s, 2H), 7.23 (d, 2 H), 7.55 (d, 2 H), 7.77 (d, 1 H), 8.04 (d, 1 H),9.95 (brs, 1 H)[0063] LC-MS m/z: 787.5 [M+H]+[0064] With the exception of using the amino-protected derivative of compound (II-4), the same procedure as inPreparation Example 1-2 was repeated to obtain a concentrated TFA salt of the title compound.
The synthetic route of 112257-19-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Celltrion, Inc.; PARK, Young Jun; JEONG, Jin-kyo; CHOI, Young Mi; LEE, Minseob; KIM, Yeon Jung; KIM, Kyoung Suk; CHOI, Joon hun; LEE, Jin Seo; CHO, Eun Joo; SONG, Hyunnam; PARK, Sung Jun; LEE, Jong-hyoup; LEE, Matthew Sangyup; LEE, In-Suk; KIM, Joon woo; HONG, Seung Suh; EP2927227; (2015); A1;,
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