Adding a certain compound to certain chemical reactions, such as: 180079-94-1, name is tert-Butyl 3-aminophenethylcarbamate, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 180079-94-1, Formula: C13H20N2O2
Production Example 30 Production of 3′,4′-dihydro-2’H-spiro[cyclobutane-1,1′-isoquinolin]-6′-amine 2 mL of 85 % phosphoric acid was added to 350 mg of the compound obtained in Production Example 29-2), and stirred at 70C for 1 hour. Further, 0.144 mL of cyclobutanone was added to it, and reacted at 140C for 3 hours, using a microwave reactor. The reaction liquid was diluted with water, then potassium carbonate was added to it, and extracted with ethyl acetate. This was washed with saturated saline water, dried with anhydrous magnesium sulfate, and the solvent was evaporated away. The crude product was purified through basic silica gel column chromatography (hexane/ethyl acetate) to obtain 157 mg of the entitled compound as a colorless oily compound. 1H-NMR (CDCl3) delta: 7.28 (1H, d, J=8.3 Hz), 6.59 (1H, dd, J=8.3, 2.9 Hz), 6.37 (1H, d, J=2.4 Hz), 3.54 (2H, s), 3.03 (2H, t, J=5.9 Hz), 2.68 (2H, t, J=6.1 Hz), 2.47-2.40 (2H, m), 2.18-2.07 (3H, m), 2.02-1.92 (1H, m)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 3-aminophenethylcarbamate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Banyu Pharmaceutical Co., Ltd.; EP2168966; (2010); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics