Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 214973-83-8, name is tert-Butyl 2-(4-bromophenyl)propan-2-ylcarbamate, A new synthetic method of this compound is introduced below., COA of Formula: C14H20BrNO2
Step 2: tert-butyl (2-(4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)phenyl)propan-2- yl)carbamate: The product from Step 1 above (6 g, 18.52 mmol, 97% purity), bis- (pinacolato)diboron (5.82 g, 22.91 mmol), palladium(II) acetate (0.107 g, 0.477 mmol), potassium acetate (5.62 g, 57.3 mmol) and XPhos (0.457 g, 0.955 mmol) were combined in MeCN (50 ml). The vessel was purged with N2 then heated at 75 C for 18 h. The reaction mixture was cooled, filtered through Celite, washing with MeCN (2 x 50 ml), and concentrated in vacuo to afford a brown oil. The residue was partitioned between DCM (50 ml) and water (50 ml). The phases were separated and the organic phase was concentrated in vacuo to afford a brown soild. The crude product was purified by columnchromatography (220 g cartridge, 0-20% EtOAc/isohexane) to afford the title compound (5.67 g, 15.1 mmol, 96% purity) as an off-white solid. LCMS (Method 1): m/z 306 (M+H- C4H8)+ at 2.83 min.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BERGENBIO AS; SHIERS, Jason John; WATTS, John Paul; ONIONS, Stuart Thomas; QUDDUS, Mohammed Abdul; WRIGGLESWORTH, Joseph William; SAMBROOK-SMITH, Colin Peter; NAYLOR, Alan; LONDESBROUGH, Derek; (444 pag.)WO2016/102672; (2016); A2;,
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