Application of 5004-88-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5004-88-6, name is 2-Amino-4,5-dimethoxybenzamide, This compound has unique chemical properties. The synthetic route is as follows.
Step a 2-((4-Chlorophenyl)carbonylamino)-4,5-dimethoxybenzamide To a solution of 2-amino-4,5-dimethoxybenzamide (2.0 g, 10.47 mmol) in THF (15 mL) and triethyl amine (3 mL, 20.91 mol) was added solution of 4-chlorobenzoyl chloride (2.2 g, 12.57 mol) in THF (5.0 mL) at rt for 10 min. The reaction mixture was stirred at rt 16 h. The solution was poured into ice cold water and stirred for 10 min. The separated solid was filtered, washed with ice cold water and dried to the product as a pale yellow color solid (2.9 g, 85%), mp 120-122 C. 1H NMR (400 MHz, DMSO-d6): delta 13.38 (1H, s), 8.48 (1H, br s), 8.33 (1H, br s), 7.94 (2H, d, J=8.0 Hz), 7.66 (1H, s), 7.65 (2H, d, J=8.0 Hz), 7.46 (1H, s), 3.84 (3H, s), 3.81 (3H, s); LC-MS (negative ion mode): m/z 333, 335 (M-H)-.
The chemical industry reduces the impact on the environment during synthesis 2-Amino-4,5-dimethoxybenzamide. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Gokaraju, Ganga Raju; Kasina, Sudhakar; Somepalli, Venkateswarlu; Gokaraju, Rama Raju; Gokaraju, Venkata Kanaka Ranga Raju; Bhupathiraju, Kiran; Golakoti, Trimurtulu; Sengupta, Krishanu; Alluri, Venkata Krishna Raju; US2013/266563; (2013); A1;,
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