Some common heterocyclic compound, 40724-47-8, name is 4-Bromomethylbenzenesulfonamide, molecular formula is C7H8BrNO2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C7H8BrNO2S
Exam le 81 4-(azidomethy 3 )benzen esul fonam id e To a stirred solution of 4-(bromomethyl)benzenesulfonamide (0.50 g) in N,Ar-dimethylformarnide (ImL) was added sodium azide (0.20 g). The suspension was heated to 50C for 3 hours at which points the solvent was removed under reduced pressure. The residue was partitioned between ethyl acetate and water. The organic phase was washed with brine, dried over magnesium sulfate, filtered and concentrated to dryness to give the title compound as a syrup that solidified on standing. NM (400 MHz, Chioroforn ) delta 8.06 — 7.91 ( rn. 2H), 7.58 FontWeight=”Bold” FontSize=”10″ – 7.44 (m, 2H), 4.96 is, 2H), 4.48 (s, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 40724-47-8, its application will become more common.
Reference:
Patent; THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT; WINTERS, Geoffrey C.; MANDEL, Alexander Laurence; RICH, James R.; HEDBERG, Bradley John; HSIEH, Tom Han Hsiao; BOURQUE, Elyse Marie Josee; BABCOOK, John; WO2014/144871; (2014); A1;,
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