Reference of 456-64-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 456-64-4, name is 1,1,1-Trifluoro-N-phenylmethanesulfonamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a-78 C solution of Preparation 30 (7.0 g, 19.1 mmol) in THF (80 mL) add potassium hexamethyldisilane (KHMDS) (53 mL, 0.5 M solution in toluene, 26.7 mmol) over 5 min. Add hexamethylphosphoramide (HMPA) (4.64 mL, 26.7 mmol) quickly, and stir the solution at-78 C for 25 min. Add a solution of N-phenyl triflamide (11.5 g, 32.2 mmol) in THF (15 mL + rinse) via syringe. Maintain the resulting solution at-78 C for 2 h, then pour the reaction contents into 1/2 SATD. NAHCO3 AND extract with ET20 (150 ML) and EtOAc (2 x 75 mL). Wash the combined organic extracts with H2O (2 x 100 mL) and brine (100 mL), dry over NA2SO4, and concentrate. Purification of the crude product by MPLC (0 to 12 to 25% EtOAc/hexanes) affords Preparation 31 (6.25 g, 66%) as an OFF-WHITE SOLID. H NMR (CDC13) 8 7.25-7. 43 (m, 5 H), 6. 84 (d, J = 8.8 Hz, 1 H), 6. 80 (dd, J = 8.8, 2.8 Hz, 1 H), 6.72 (d, J = 2. 8 Hz, 1 H), 5.02 (s, 2 H), 4.04 (m, 4 H), 3. 82 (dd, J = 4.4, 12. 8 Hz, 1 H), 2.66 (dq, J = 14.0, 2.4 Hz, 1 H), 2.21 (m, 2 H), 1.91 (m, 1 H), 1. 80 (t, J = 12.8 Hz, 1 H), 1.64 (TD, J = 12.8, 4.4 Hz, 1 H).
The synthetic route of 1,1,1-Trifluoro-N-phenylmethanesulfonamide has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ELI LILLY AND COMPANY; WO2004/94400; (2004); A2;,
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