Synthetic Route of 10268-06-1, The chemical industry reduces the impact on the environment during synthesis 10268-06-1, name is 2-(2-Chlorophenyl)acetamide, I believe this compound will play a more active role in future production and life.
A mixture of Compound 1c (322 mg, 0.857 mmol) and Compound 1d (121 mg, 0.714 mmol) in 7 ML of anhydrous THF was stirred under nitrogen and cooled in an ice bath while treating dropwise with 2.9 ML of 1 N potassium t-butoxide in THF. The mixture was stirred for 30 minutes in an ice bath then at room temperature for another 30 min.The reddish mixture was then cooled down and then 2 ML of concentrated HCl was added dropwise.The mixture was stirred for 5 min.ethyl acetate (150 ML) and H2O (30 ML) were added.The organic layer was separated and washed with saturated NaHCO3 and brine, dried over anhydrous sodium sulfate and concentrated in vacuo.The crude product was separated by flash chromatography on silica gel (CH2Cl2/MeOH/NH4OH, from 98:2:0.2 to 95:5:0.5) to yield 150 mg (55percent) of Compound 1 as a yellow solid. 1H NMR (CDCl3) delta 8.21 (dd, J=1.5, 4.7 Hz, 1H), 8.17 (s, 1H), 7.48-7.33 (m, 4H), 6.78 (dd, J=4.7, 8.1 Hz, 1H), 6.66 (dd, J=1.5, 8.1 Hz, 1H), 4.5 (dd, J=2.6, 7.1 Hz, 2H), 3.41 (t, J=5.5 Hz, 2H), 2.03 (m, 2H). ES-MS m/z 382 (MH+). Using the procedure of Example 1 and the appropriate reagents and starting materials known to those skilled in the art, other compounds of the present invention may be prepared including, but not limited to
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-Chlorophenyl)acetamide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Zhang, Han-Cheng; Kuo, Gee-Hong; Maryanoff, Bruce E.; Ye, Hong; O’Neill, David; Shen, Lan; Demarest, Keith; Conway, Bruce R.; McComsey, David F.; US2004/6095; (2004); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics