Electric Literature of 75175-77-8, The chemical industry reduces the impact on the environment during synthesis 75175-77-8, name is 3-(4-Fluorophenyl)-N,N-dimethylacrylamide, I believe this compound will play a more active role in future production and life.
General procedure: Enaminones 1 (1.0 mmol), amines 2 (1.0 mmol), isatin 3 (1.0 mmol), p-xylene (10 ml), and trifluoroacetic acid (TFA) (0.2 ml) were charged into a 25 ml round-bottom flask, and the mixture was stirred at 130C for 20 min until the enaminones 1 were completely consumed. The mixture was cooled to room temperature, neutralized with a saturated solution of Na2CO3 to pH 8-9, and then EtOAc (30 ml¡Á2) was added. The organic phase was washed with water (20 ml), dried over Na2SO4, concentrated, and purified by flash column chromatography to afford pyrrolo[3,4-c]quinoline-1-one derivatives 4 in a 60-82% yield. The products were further identified by FTIR, NMR, and HRMS, and were found to be in good agreement with the assigned structures (see Supplementary data).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(4-Fluorophenyl)-N,N-dimethylacrylamide, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Yu, Fu-Chao; Zhou, Bei; Xu, Hui; Li, Ya-Min; Lin, Jun; Yan, Sheng-Jiao; Shen, Yuehai; Tetrahedron; vol. 71; 7; (2015); p. 1036 – 1044;,
Amide – Wikipedia,
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