Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16091-26-2, name is 3′-Aminobenzanilide, A new synthetic method of this compound is introduced below., Recommanded Product: 3′-Aminobenzanilide
General procedure: Compound (1a-e) (1 eq.) and compound (2a-e) (1 eq.) were suspendedin 5 mL of glacial acetic acid. The suspension dissolved completely uponheating. The reaction was refluxed for 15-30 min. After completion ofreaction (as monitored by TLC), reaction mixture was allowed tocooled, and then 10 mL of water was added. The resulting precipitatewas then filtered and was washed with water, cold ethanol, and hexanesto give the product.25N-(3-(2-methyl-4-oxoquinazolin-3(4H)-yl)phenyl) benzamide (4a):TLC carried out in Hexane: Ethyl acetate (60:40) Rf=0.13; cream colorsolid (70%); M.P: 248-249 C; IR: 3290 cm-1 (NeH stretch),1658 cm-1 (C]O amide); HRMS: m/z calcd for C22H17N3O2: 355.39[M+H]+; found: 356.1565.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Qureshi, Shahnawaz I.; Chaudhari, Hemchandra K.; Bioorganic and Medicinal Chemistry; vol. 27; 12; (2019); p. 2676 – 2688;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics