191170-76-0, name is Benzyl 4-bromophenethylcarbamate, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C16H16BrNO2
To a solution of benzyl 4-bromophenethylcarbamate (13.7 g, 41.1 mmol) in DMF (40 mL) was added Zn(CN)2 (4.93 g, 41.2 mmol) and Pd(PPh3)4 (4.75 g, 4.11 mmol). The reaction mixture was stirred at 100 C under Ni overnight. TLC showed the reaction completed. The reaction mixture was quenched with water and filtered. The residue was stirred in a mixed solvent of ethyl acetate and hexane (100 mL, EtOAc:Hexane = 1 :6) for 30 min. It was next filtered and dried to afford the title compound as white solid (8.9 g, 77.6%). NMR (500 MHz, DMSO- d6): 7.74 (d, 2H), 7.28-7.41 (m, 8H), 4.99 (s, 2H), 3.25-3.29 (m, 2H), 2.81 (t, 2H).
The synthetic route of 191170-76-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ZHEJIANG VIMGREEN PHARMACEUTICALS, LTD; SUN, Sanxing; YE, Jinqi; ZHAO, Long; HU, Chongbo; CHEN, Zhengshu; (0 pag.)WO2020/2968; (2020); A1;,
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