Related Products of 35303-76-5, A common heterocyclic compound, 35303-76-5, name is 4-(2-Aminoethyl)benzenesulfonamide, molecular formula is C8H12N2O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: The 1.0M solution of 4-amino-/aminomethyl-/aminoethyl-benzenesulfonamide (1 equiv) in acetone (100mL) was added dropwise into a vigorously stirred suspension of cyanuric chloride (1 equiv) in acetone (100mL) at 0C. The white reaction mixture was stirred at the same temperature for 30min. After that the 1.7M aqueous solution of NaOH (1 equiv) was added during a period of 20min. Stirring was continued for 1h, and the reaction was quenched by the addition of slush (100mL). After reaction was completed, the resulted solid was filtered off, washed and dried under high vacuum. The product was crystalized from acetone affording the compounds 1-3 as a white solid.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Miku?, Peter; Kraj?iova, Dominika; Mikulova, Maria; Horvath, Branislav; Pecher, Daniel; Garaj, Vladimir; Bua, Silvia; Angeli, Andrea; Supuran, Claudiu T.; Bioorganic Chemistry; vol. 81; (2018); p. 241 – 252;,
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