Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 108468-00-4, name is 1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene, A new synthetic method of this compound is introduced below., Recommanded Product: 108468-00-4
HOBT (1.45 g, 10.9 mmol) is added to a solution of {3-[3-(3-carboxymethoxyprop-1-ynyl)phenyl]prop-2-ynyloxy}acetic acid (A30, 0.40 g, 1.3 mmol) and 4-N-tert-butoxycarbonylaminomethylbenzylamine (1.2 g, 5.2 mmol) in absolute CH2Cl2 (20 ml) and Et3N (2.5 ml), and the mixture is stirred at RT for 45 min. EDC (2.1 g, 10.9 mmol) is then added, and the mixture is stirred at RT overnight. The reaction solution is diluted with CH2Cl2 (15 ml) and extracted (2¡Á) with semisaturated aqueous NH4Cl solution (25 ml), dried over MgSO4, filtered off and concentrated under reduced pressure. Further purification by chromatography [Tol/Ac (8:2)] over a silica gel column gives the title compound (1.1 g) as a colorless powder. TLC, silica gel, glass plates, [Tol/Ac (7:3)], Rf=0.51.MS: calc.: C42H50N4O8 (738.0), found: [MH+] 738.8, [MNH4+] 755.8; [MNa+] 761.2
The synthetic route of 108468-00-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Altana Pharma AG; US6960588; (2005); B1;,
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