Application of 94838-59-2, These common heterocyclic compound, 94838-59-2, name is tert-Butyl 4-aminophenethylcarbamate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 3-(4-methylpiperazin-l-yl)propanoic acid (172 mg, 1 mmol), HATU (456 mg, 1.2 mmol), DIPEA (323 mg, 2.5 mmol) and /ert-butyl 4-aminophenethylcarbamate (236 mg, 1 mmol) in DCM (10 mL) was stirred at room temperature overnight. TLC showed the reaction completed. The reaction mixture was concentrated and purified by column chromatography to afford the title compound as yellow solid (90mg, 23.0% yield). NMR (500 MHz, DMSO-riri) S: 10.01 (s, 1H), 7.48 (d, J= 8.4 Hz, 2H), 7.10 (d, J= 8.4 Hz, 2H), 6.84 (dd, J= 13.1, 6.9 Hz, 1H), 3.10 (dd, J= 14.1, 6.4 Hz, 2H), 2.64 (dd, .7= 24.9, 17.1 Hz, 6H), 2.45 (dd, J= 15.8, 8.8 Hz, 8H), 2.20 (d, J= 12.1 Hz, 3H), 1.37 (d, J= 1.6 Hz, 9H).
The synthetic route of 94838-59-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ZHEJIANG VIMGREEN PHARMACEUTICALS, LTD; SUN, Sanxing; ZHAO, Long; HU, Chongbo; CHEN, Zhengshu; YE, Jinqi; (0 pag.)WO2020/2969; (2020); A1;,
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