In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 354-38-1, name is 2,2,2-Trifluoroacetamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 2,2,2-Trifluoroacetamide
General procedure: To a solution of trifluoroacetamide (2.00 g,18 mmol), NaI (7.95 g, 53 mmol) and styrene (2.05 mL, 18 mmol) in CH3CN (80 mL) t-BuOCl (6.10 mL, 53 mmol) was added dropwise in argon atmosphere in the dark and cooling to 10 C . The mixture was stirred for one day, the solvent removed under reduced pressure, the residue dissolved in diethyl ether (80 mL), washed with aqueous Na2S2O3 and dried over CaCl2. The solvent was removed in vacuum. Purification of the residue (5.57 g) by separation from resinification products on silica column with successive elution with hexane, ether-hexane (1:1) and ether recovered trifluoroacetamide (0.4 g) and gave the title compound (9) (4.80 g, 79%), which was crystallized from methylene chloride. Colorless crystals, mp 109 C . gammamax (KBr) 3324, 3088, 3035, 2972,2951, 2913, 1699, 1553, 1496, 1455, 1365, 1216, 1182, 1076, 999, 885,804, 762, 729, 702, 655, 599, 573, 498 cm-1; deltaH (CDCl3), ppm: 7.45-7.35 (2H,m,CH), 7.33-7.26 (3H, m, CH), 7.00 (1H,d, J 5.5 Hz,NH), 5.14 (1H, ddd, J 7.1, 5.9, 5.5 Hz,CH), 3.58 (1H, dd, J 10.7, 5.9 Hz, CHB), 3.54 (1H, dd, J 10.7, 7.1 Hz, CHA); deltaC (CDCl3), ppm: 157.0 (q, J 37.6 Hz,C=O), 138.1 (Ci), 129.5 (Cm), 129.2 (Cp), 126.5 (Co), 116.0 (CF3, J 288.5 Hz), 54.9 (CHNH) 8.7 (ICH2).19F NMR, deltaF, ppm: 75.36. Anal. Calcd: C, 35.01; H, 2.64; N, 4.08; I 36.99; F 16.61. C10H9F3INO.Found: C, 35.02; H, 2.53; N, 3.98; I 37.10; F 16.56.
The synthetic route of 354-38-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Shainyan, Bagrat A.; Moskalik, Mikhail Yu.; Astakhova, Vera V.; Sterkhova, Irina V.; Ushakov, Igor A.; Tetrahedron; vol. 71; 45; (2015); p. 8669 – 8675;,
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