Related Products of 1408282-26-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1408282-26-7 as follows.
Example 1 Preparation of 2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one (Formula IV) 8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one (Formula V) 100 gm was dissolved in dichloromethane (1000 ml). Pyridinium tribromide (200 gm) was added in the above solution and stirred at 0-5 C. until completion of reaction. Once reaction was complete saturated sodium carbonate solution (500 ml) was added and stirred for 2 hours. The solid was filtered and washed with water (200 ml). The wet cake was taken in acetonitrile (150 ml) and DIPE (150 ml) and stirred at RT for 1 hour. The obtained solid was filtered and washed with acetonitrile (50 ml). The material was dried at 50 C. to get 2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one (Formula IV) (110 gm).
According to the analysis of related databases, 1408282-26-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; RK Pharma Solutions LLC; Kovi, Ravishanker; Kannapan, Jayaraman; Thirunavakarasu, Ananda Babu; Mande, Hemant; US2019/233428; (2019); A1;,
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