Some common heterocyclic compound, 25900-61-2, name is 3-Amino-N-methylbenzamide, molecular formula is C8H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 3-Amino-N-methylbenzamide
A solution of 7-methanesulfinyl-3-(2,6-dichloro-phenyl)-1-methyl-1H-pyrimido[4,5-e][1,3,4]oxadiazine (0.10 g, 0.28 mmol), N-methyl-3-amino-benzamide (84 mg, 0.56 mmol) and p-toluenesulfonic acid monohydrate (53.3 mg, 0.28 mmol) (Aldrich) in isopropanol (4 ML) was placed in a microwave reactor (SmithSynthesizer).The reaction mixture was heated at 170 C. for 1 h.The reaction mixture was concentrated and purified by RP-HPLC (C-18, eluding with MeCN/H2O) to obtain a solid which was recrystallized from methanol to afford the product. (Yield 34 mg, 28%). HRMS m/z Calculated for C20H16Cl2N6O2 [(M+H)+]: 443.0785. Found: 443.0791.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 25900-61-2, its application will become more common.
Reference:
Patent; Chen, Jian Jeffrey; Luk, Kin-Chun Thomas; US2004/97493; (2004); A1;,
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