Sources of common compounds: 366-49-4

The synthetic route of 2-Acetamido-4-fluorotoluene has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 366-49-4, name is 2-Acetamido-4-fluorotoluene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 2-Acetamido-4-fluorotoluene

To a stirred solution of DMF (3 mL) at 00C was added phosphorus oxychloride (12 mL, 126 mmol) over 30 minutes, keeping the internal temperature below 7C. N-(5- Fluoro-2-methylphenyl)acetamide (2 g, 12 mmol) was added to the solution and heated to 85C overnight. The reaction was cooled to room temperature and added dropwise to water (50 mL). The precipitate was collected by filtration, washed with water and dried in the vacuum oven to give the title compound (274 mg, 10%) as a yellow solid. 5H (CDCl3) 10.58 (s, IH), 9.01 (s, IH), 7.60-7.70 (m, IH), 7.15-7.25 (m, IH), 2.75 (s, 3H).

The synthetic route of 2-Acetamido-4-fluorotoluene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UCB PHARMA S.A.; WO2009/81105; (2009); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics