Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2832-19-1, name is 2-Chloro-N-(hydroxymethyl)acetamide, A new synthetic method of this compound is introduced below., COA of Formula: C3H6ClNO2
EXAMPLE 19 [2-(AMINOMETHYL)-3, 5-DI-TERT-BUTYLPHENOL HYDROCHLORIDE] Step A: [2-CHLORO-N-(2, 4-DI-TEYT-BUTYL-6-HYDROXYBENZYL)] acetamide A finely powdered mixture of 5.2 g (25 mmol) of 3, 5-di-tert- butylphenol and 3.15 g (25 mmol) [OF N-HYDROXYMETHYL-2-CHLOROACETAMIDE] was added in portions to a vigorously stirred solution of 22.5 mL acetic acid and 2.5 mL (98%) sulfuric acid at [0-10C.] The reaction mixture was allowed to warm to room temperature over several hours, and stirring was maintained for a total of 16 hours. The reaction mixture was poured into ice-water, neutralized with saturated aqueous [NAHCO3] solution and extracted into CH2C12. The organic extracts were combined, washed with brine, dried [(NA2SO4),] filtered and evaporated. The residue was purified on a silica gel flash chromatography column eluted with 15-30-50% EtOAc in hexane. Evaporation of the purified fractions and [DRYING’IN VACUO] afforded the title compound.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MERCK & CO., INC.; WO2004/783; (2003); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics