Adding a certain compound to certain chemical reactions, such as: 201162-53-0, name is 3-Boc-3,8-Diazabicyclo[3.2.1]octane, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 201162-53-0, Recommanded Product: 201162-53-0
Tertbutyl 3,8-diazabicyclo[3 .2.ljoctane-3-carboxylate (250 mg, 1.18 mmol), 5-bromopicolinic acid (0.309g, 1.53 mmol), sodium 2-methylpropan-2-olate (0.283 g, 2.94 mmol), methanesulfonato(2-dicyclohexylphosphino-2?,6?-di-i-propoxy- 1,1 ?-biphenyl)(2-amino- 1,1biphenyl-2-yl)palladium(II) (0.04 9 g, 0.05 9 mmol) and 1 ,4-dioxane (4 mL) were charged in a vial. The headspace was flushed with nitrogen and the reaction mixture was degassed using 4 cycles of vacuum and nitrogen refilling. The reaction was heated at 110 C for 36 h then cooled to room temperature. Silica gel was added and the solvent was removed under vacuum. The desired product was purified by silica gel chromatography (eluting with hexane/ ethyl acetatemethanol). LCMS M/Z (M+H) 334.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Boc-3,8-Diazabicyclo[3.2.1]octane, and friends who are interested can also refer to it.
Reference:
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; COTE, Alexandre; CRAWFORD, Terry; DUPLESSIS, Martin; GOOD, Andrew, Charles; LEBLANC, Yves; MAGNUSON, Steven, R.; NASVESCHUK, Christopher, G.; ROMERO, F. Anthony; TANG, Yong; TAYLOR, Alexander, M.; (271 pag.)WO2016/138114; (2016); A1;,
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