In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1943-79-9 as follows. category: amides-buliding-blocks
General procedure: alpha-amino methyl ester hydrochloride (2 mmol) and carbamate (2.2 mmol) were dissolved in amixture of acetonitrile (12 ml) and triethylamine (6 ml) and reaction mixture was refluxed for 10h. Then, NaOH (5 mmol) was added and reaction was continued for another 8 hours. After thecompletion of the reaction, solvents were distilled off, and the residue was partitioned betweenethyl acetate and 0.1N aqueous HCl and extracted. The organic layer was washed with brine followed by drying over anhydrous Na2SO4. The concentration of the organic layer gave thecrude product which was purified either by recrystallization (hexane-ethyl acetate mixture) or bycolumn chromatography (hexane:ethylacetate) to afford the desired product.
According to the analysis of related databases, 1943-79-9, the application of this compound in the production field has become more and more popular.
Reference:
Article; Tanwar, Dinesh Kumar; Ratan, Anjali; Gill, Manjinder Singh; Synlett; vol. 28; 17; (2017); p. 2285 – 2290;,
Amide – Wikipedia,
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